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Little is known about the signaling pathways that control the self-renewal of the germline stem cell (GSC) in the adult gonad. Here, we show that Cdc42 is required for GSC self-renewal in Xenopus. Although Cdc42 is active throughout the GSC lineage and has been shown to regulate GSC division, Cdc42 is normally absent from the GSCs themselves. We found that GSCs lack Cdc42, but have Cdc42-independent and Cdc42-dependent pools of Rac1, a small GTPase that is activated by Cdc42 and known to regulate GSC division. The lack of Cdc42 in the GSCs is due to the cell-autonomous requirement for Cdc42 in the GSCs to initiate and maintain the self-renewal of the GSCs, but to exclude the GSCs from the germline. In addition, activation of Cdc42 in the GSCs is required for their proliferation and/or differentiation into cystocytes. These results identify a molecular requirement for Cdc42 in GSC self-renewal and reveal that the GSCs normally utilize a Cdc42-dependent mechanism to maintain the quiescence of the GSCs. The requirement for Cdc42 in the GSCs may be the basis for the error prone cell-autonomous regulation of GSC self-renewal.Q:
What are the implications of using.nav-tabs with AngularJS
I was reading about nav-tabs in AngularJS and noticed that Angular's official documentation says to use the ng-click attribute. If you click anywhere else on the page, the page is 'ticked' and not a 0b46394aab
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